Chemist at work
Thirteen Early Stage Researchers (ESRs) have been working on four sub-programmes ('projects') of research within the theme of anti-cancer natural product total synthesis and medicinal chemistry. The projects inter-connect through common chemical methodologies and new reaction technologies to generate a series of compounds with promising anti-cancer activities:
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As the research has progressed, regular consultation with Associated Partners in chemical technology (biocatalysis and electrosynthesis) and reaction technology (flow) ensured that the students were exposed to projected applications of these technologies, where feasible, in place of classical methods. The ESRs' synthetic work has generated compounds for assay against various cancer cell lines; promising and simplified compounds have been collected for further bioassay, and iteration, with expert guidance from a team of cancer biology advisers.